Understanding Pharmacodynamics of Butyl Isobutyl Phthalate: Where In vitro and In silico Studies Converge

Recent epidemiological studies suggest that postprandial hyperglycemia is an independent risk factor for cardiovascular disease. A human’s high carbohydrate diet majorly consists of a and α-glucosidase glucosidase located in the brush border small intestine involved glycosidic cleavage starch at α-glycosidic bonds. inhibitors are unique class anti-diabetic drugs particularly useful individuals with diet. works by competitively inhibiting enzyme intestines, thus delaying digestion complex intestinal absorption glucose. Hence, present study, inhibition activity butyl isobutyl phthalate isolated from chloroform fraction Rubus steudneri leaves investigated its possible mechanism action ascertained silico. The compound was found to exhibit concentration-dependent half-maximal inhibitory concentration value 10.68 g/ml. results vitro assay were promising substantiated molecular docking dynamics studies.